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Severe Outflow by R. Edwards

A Thanksgiving Message

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Thanksgiving: an annual holiday meant to serve as a day of gratitude, a reminder to count blessings and show our appreciation for them. I only need to look as far as the faces of my wife and grown children to see how blessed I am. I hope you can find similar solace in someone(s) you love, and in something about your daily situation, while recognizing it’s not necessarily easy.

Many of our friends and family members have had hard times this year—seemingly more than usual. I think of those who have endured natural, criminal and suicidal deaths of loved ones, chronic physical or mental illness of self or a family member, severe acute sickness or injury, shattered relationships, financial hardship, job loss, homelessness or a looming threat thereof, or simply trying to raise kids and get by in a world that seems to be getting more insane by the year.

Right off the top of my head, I can sit here for just half a minute and think of 20, 30 or more people I know who have been dealing with just those kinds of problems, and others too. Their (your) faces flash before me like a newsreel of tough times. If this speaks to you, know you’re not alone, and that you are the subject of prayers for overcoming, that your story can invert from troubled to triumphant. It won’t be easy, and it could take awhile…but with the Lord, all good is possible.

In times like these, it can be hard to find things for which to be grateful. Life itself, something we too often take for granted, and something for which we should be thankful, may seem fruitless or pointless at times. Know you’ve got other people and a Lord who care, even if you don’t hear that enough.

Thanksgiving is about far more than turkeys, messy kitchens, gatherings around big tables, football, and that loudmouthed activist in the family ranting about politics at dinner. Cutting through all that, it’s about thankfulness. Whether your day will be full of relatives or a party of one, think of those people, pets, memories, and comforting items for which you’re grateful. Hold to those, cherish them, and offer thanks for the true friends and loved ones in your life, whether bountiful or few. There are some, I promise.

Moreover, take a minute to tell and show them your gratitude. Doing so only costs that little bit of time, and it pays off a hundredfold in good will and appreciation.

If you’re reading this, know that regardless of your profession, avocations, politics, or worldview, I appreciate you in some way or another, whether or not I have said so individually. You are a child of God, loved and valued despite all your flaws, just as I am, despite all mine. It’s difficult to keep that in mind sometimes, especially as hard as we can be on ourselves. But it’s true.

Thank you for reading, for understanding, and for being here. Happy Thanksgiving!

Heavy Blow to Scientific Credibility

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The entire theory (and research thereon) that Alzheimer’s disease is caused by “amyloid beta” protein plaques, which has been around since a widely publicized and seminal 2006 paper, now teeters on the brink of implosion, or at least deep and major reworking. A six-month Science magazine-supported investigation reveals “doctored” (pun not intended, but fits) medical imaging of the sufferers’ brains. Those images appeared inside that first paper, other papers by the same authors, and on down through more papers by others that used the original work and data as a foundation.

Many tens of millions of dollars of research, across 16 years of elapsed time, is at risk, thanks to irreproducibility and perhaps outright tampering. That risk includes waste of a lot of taxpayer funding. If these images contain bogus alterations (in effect, unethically altering data to fit hypotheses), as independent analysis hired by Science magazine have affirmed, this could become the greatest scientific scandal of our time, and that’s saying something.

Science (the profession), and medical science in particular, are having a tough time reputationally right now — most of it not deserved, but some of it well-earned, unfortunately. Science (the profession) doesn’t need any more body blows to credibility. The great majority of scientists are honest and ethical. I know many in meteorology and other geosciences, and even a few in medicine. Scientists absolutely should be held to utmost high ethical standards. Still, as with any profession, human nature can infest science with bad actors too — some of whom are smart enough to get away with it, at least for awhile.

Yes, science is self-correcting, but the time for that with this topic was *before* publication, during peer review — or at the very latest, independent reproduction shortly after with retractions…but not 16 years and countless research time and money later. Better late than never in exposing potential misconduct, of course — but this has a uniquely foul stench due to the broad impact. It’s not some obscure work with an audience of ten, investigating the electrical conductivity of a piece of tree bark in Tasmania. Instead this is a horrid disease that impacts millions of people, now and future, with enormous social and economic cost, and most of us know someone(s) affected.

As a (non-medical) scientist and photographer, who is also a journal editor, I care about experimental and data reproducibility, photographic & science ethics, as well as waste of taxpayers’ research funding. I’ve also lost friends and colleagues to Alzheimer’s disease. That all makes this revelation rather infuriating.

Please read the full, long-form article (linked here again) for the full story. Here is an excerpt:

If Schrag’s doubts are correct, Lesné’s findings were an elaborate mirage.

Schrag, who had not publicly revealed his role as a whistleblower until this article, avoids the word “fraud” in his critiques of Lesné’s work and the Cassava-related studies and does not claim to have proved misconduct. That would require access to original, complete, unpublished images and in some cases raw numerical data. “I focus on what we can see in the published images, and describe them as red flags, not final conclusions,” he says. “The data should speak for itself.”

A 6-month investigation by Science provided strong support for Schrag’s suspicions and raised questions about Lesné’s research. A leading independent image analyst and several top Alzheimer’s researchers—including George Perry of the University of Texas, San Antonio, and John Forsayeth of the University of California, San Francisco (UCSF)—reviewed most of Schrag’s findings at Science’s request. They concurred with his overall conclusions, which cast doubt on hundreds of images, including more than 70 in Lesné’s papers. Some look like “shockingly blatant” examples of image tampering, says Donna Wilcock, an Alzheimer’s expert at the University of Kentucky.

The authors “appeared to have composed figures by piecing together parts of photos from different experiments,” says Elisabeth Bik, a molecular biologist and well-known forensic image consultant. “The obtained experimental results might not have been the desired results, and that data might have been changed to … better fit a hypothesis.”

The Fallacy of “Compromise” with Gaslighting Forces of Tyranny

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Compromise is great for business deals, arbitration, professional workplace disagreements, property-line disputes, and the like. At lawmaking governance levels, it’s often needed to get something done (say, to get enough legislators of the opposition party aboard to pass a budget).

However, compromise is, like most concepts involving social interaction, prone to abuse.

Stay alert to ways you can be compromised adversely, manipulated and taken advantage of, and resist those — whether at personal levels by abusive “friends” and “lovers”, or on larger scales, by government and media. Yes, you can be on the hurt side of an abusive relationship with a governing authority. History is chock full of examples.

A large-scale, abusive use of the concept of compromise is when high authorities wish to restrict the liberty of the people. That’s called tyranny. Genocides under Stalin, Hitler, Mao, and Pol Pot are famous large-scale examples just in the last 100 years. Without quite as much overt killing (yet still a lot, per the Uighurs), is the ongoing, worsening, Orwellian techno-control dictatorship in mainland China.

Less extreme, but just as insidious, are slow-drip, incremental tactics here and anywhere else in the so-called Free World, acclimatizing people to each seemingly minuscule sacrifice of freedom, until one day, you are in a de facto prison. How does that occur? Convince you to give up your own liberty, and it’s rather easy.

Gaslighting occurs not just in personal relationships, but by Big Bureaucracy. Situational types:
“Confused? We’re the experts at telling you what’s real, all else is disinformation.”
“Here, this pain I’m doling out is for your own good.”

We’re conditioned early to these vulnerabilities by having to accept needed pain as kids, at the behest of parents — such as by enduring awful-tasting medicines, painful shots, or stinging antiseptics applied to scrapes, that truly were for our own good. This conditioning renders us vulnerable to systemic, governance-level gaslighting as adults, via the same persuasive tactics. Furthermore, the process can be sudden, or creep along in tiny steps spanning years, or even generations. Generations!

Don’t we owe it to our children, and theirs, to ensure their liberties are greater than ours, not less?

At societal scales, freedom almost never returns after being sacrificed for what command-and-control figures plea is the “common good”. Who are they to define it? Who are they to make my decisions for me regarding anything I do that doesn’t directly and provably (in a legal, beyond-reasonable doubt sense) harm another individual?

Better it is to leave “common good” decisions to local scales, where groups of neighbors can better contextualize solutions to local needs. Neighborhoods and towns, perhaps even cities if not too large and diverse, work best. Above that, the bigger the scale of government, the greater the fallacy of “common good” when it comes to anything affecting freedom. Why? Simple: one size doesn’t fit all. In a physically and culturally vast nation like ours, the people and their situations are too diverse (by the true meaning of diversity) for that.

To wit, water restrictions in Las Vegas are rather inappropriate for Upper Michigan, on whose shores wash the three biggest Great Lakes. Fuel taxes hurt the Kansas wheat farmer or the poverty-level working single mom in Bakersfield more than the Boston loft dweller with no car. The same federal and state red tape involving business books and taxes burdens the margin-straddling machine shop in Minnetonka proportionately harder than the Minnesota Vikings, whose owner hires legions of accountants at the snap of a finger. Even within one city, zoning must vary, because development, drainage and land-use needs are nonuniform. More examples abound, by the millions, in countless situations.

Big bureaucracy commonly imposes, after gaslighting us into accepting they’re for our own benefit, or the benefit of others, one-size “solutions” justified off “the common good”. Again one size does not fit all.

Beware simple tactics of propaganda, such as the use of the words “compassion” or “empathy” in the political context; those are quite often little tools of psychological manipulation to soften resistance against top-down theft of freedoms. Bureaucracy cannot have “compassion” nor “empathy”. Only individuals and God can.

Freedom is God-given, per the concept of free will. As the Founders rightly recognized and wrote, our rights come not from the government, but are bestowed by the Creator on the governed. Liberty is a divinely inspired ideal! We should treat it as no less important than that.

Give the agents of tyranny an inch, and they’ll take a mile. Therefore, those who value life and liberty should not yield even an inch to those who wish to take it. “Compromise” with tyranny only incrementalizes its takeover.